LOCUS Tyr 3308 bp mRNA linear ROD 07-JAN-2002 DEFINITION Mus musculus tyrosinase (Tyr), mRNA. ACCESSION NM_011661 VERSION NM_011661.1 GI:6755912 KEYWORDS . SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (bases 1 to 3308) AUTHORS Kwon,B.S., Wakulchik,M., Haq,A.K., Halaban,R. and Kestler,D. TITLE Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression JOURNAL Biochem. Biophys. Res. Commun. 153 (3), 1301-1309 (1988) MEDLINE 88268910 PUBMED 3134020 REFERENCE 2 (bases 1 to 3308) AUTHORS Muller,G., Ruppert,S., Schmid,E. and Schutz,G. TITLE Functional analysis of alternatively spliced tyrosinase gene transcripts JOURNAL EMBO J. 7 (9), 2723-2730 (1988) MEDLINE 89030636 PUBMED 3141148 REFERENCE 3 (bases 1 to 3308) AUTHORS Terao,M., Tabe,L., Garattini,E., Sartori,D., Studer,M. and Mintz,B. TITLE Isolation and characterization of variant cDNAs encoding mouse tyrosinase JOURNAL Biochem. Biophys. Res. Commun. 159 (2), 848-853 (1989) MEDLINE 89193679 PUBMED 2494997 REFERENCE 4 (bases 1 to 3308) AUTHORS Yamamoto,H., Takeuchi,S., Kudo,T., Sato,C. and Takeuchi,T. TITLE Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA JOURNAL Jpn. J. Genet. 64 (2), 121-135 (1989) MEDLINE 90212084 PUBMED 2517217 REFERENCE 5 (bases 1 to 3308) AUTHORS Kwon,B.S., Halaban,R. and Chintamaneni,C. TITLE Molecular basis of mouse Himalayan mutation JOURNAL Biochem. Biophys. Res. Commun. 161 (1), 252-260 (1989) MEDLINE 89273644 PUBMED 2567165 REFERENCE 6 (bases 1 to 3308) AUTHORS Shibahara,S., Okinaga,S., Tomita,Y., Takeda,A., Yamamoto,H., Sato,M. and Takeuchi,T. TITLE A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85 JOURNAL Eur. J. Biochem. 189 (2), 455-461 (1990) MEDLINE 90249393 PUBMED 2110899 REFERENCE 7 (bases 1 to 3308) AUTHORS Carninci,P., Shibata,Y., Hayatsu,N., Sugahara,Y., Shibata,K., Itoh,M., Konno,H., Okazaki,Y., Muramatsu,M. and Hayashizaki,Y. TITLE Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes JOURNAL Genome Res. 10 (10), 1617-1630 (2000) MEDLINE 20499374 PUBMED 11042159 REFERENCE 8 (bases 1 to 3308) AUTHORS Shibata,K., Itoh,M., Aizawa,K., Nagaoka,S., Sasaki,N., Carninci,P., Konno,H., Akiyama,J., Nishi,K., Kitsunai,T., Tashiro,H., Itoh,M., Sumi,N., Ishii,Y., Nakamura,S., Hazama,M., Nishine,T., Harada,A., Yamamoto,R., Matsumoto,H., Sakaguchi,S., Ikegami,T., Kashiwagi,K., Fujiwake,S., Inoue,K. and Togawa,Y. TITLE RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer JOURNAL Genome Res. 10 (11), 1757-1771 (2000) MEDLINE 20530913 PUBMED 11076861 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M24560.1. FEATURES Location/Qualifiers source 1..3308 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="7" /map="7 44.0 cM" gene 1..3308 /gene="Tyr" /db_xref="LocusID:22173" /db_xref="MGI:98880" CDS 62..1663 /gene="Tyr" /codon_start=1 /product="tyrosinase" /protein_id="NP_035791.1" /db_xref="GI:6755913" /db_xref="LocusID:22173" /db_xref="MGI:98880" /translation="MFLAVLYCLLWSFQISDGHFPRACASSKNLLAKECCPPWMGDGS PCGQLSGRGSCQDILLSSAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGN CKFGFGGPNCTEKRVLIRRNIFDLSVSEKNKFFSYLTLAKHTISSVYVIPTGTYGQMN NGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLW EQEIRELTGDENFTVPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWQIIC SRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDR TANFSFRNTLEGFASPLTGIADPSQSSMHNALHIFMNGTMSQVQGSANDPIFLLHHAF VDSIFEQWLRRHRPLLEVYPEANAPIGHNRDSYMVPFIPLYRNGDFFITSKDLGYDYS YLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVIAAALSGLSSRLCLQKKKKKK QPQEERQPLLMDKDDYHSLLYQSHL" misc_feature 398..1429 /gene="Tyr" /note="tyrosinase; Region: Common central domain of tyrosinase" /db_xref="CDD:pfam00264" polyA_signal 1873..1878 /gene="Tyr" polyA_signal 3285..3290 /gene="Tyr" BASE COUNT 947 a 658 c 648 g 1055 t ORIGIN 1 caaagaagac tgtgacactc attaacctat tggtgcagat tttgtatgat ctaaaggaga 61 aatgttcttg gctgttttgt attgccttct gtggagtttc cagatctctg atggccattt 121 tcctcgagcc tgtgcctcct ctaagaactt gttggcaaaa gaatgctgcc caccatggat 181 gggtgatggg agtccctgcg gccagctttc aggcagaggt tcctgccagg atatccttct 241 gtccagtgca ccatctggac ctcagttccc cttcaaaggg gtggatgacc gtgagtcctg 301 gccctctgtg ttttataata ggacctgcca gtgctcaggc aacttcatgg gtttcaactg 361 cggaaactgt aagtttggat ttgggggccc aaattgtaca gagaagcgag tcttgattag 421 aagaaacatt tttgatttga gtgtctccga aaagaataag ttcttttctt acctcacttt 481 agcaaaacat actatcagct cagtctatgt catccccaca ggcacctatg gccaaatgaa 541 caatgggtca acacccatgt ttaatgatat caacatctac gacctctttg tatggatgca 601 ttactatgtg tcaagggaca cactgcttgg gggctctgaa atatggaggg acattgattt 661 tgcccatgaa gcaccagggt ttctgccttg gcacagactt ttcttgttat tgtgggaaca 721 agaaattcga gaactaactg gggatgagaa cttcactgtt ccatactggg attggagaga 781 tgcagaaaac tgtgacattt gcacagatga gtacttggga ggtcgtcacc ctgaaaatcc 841 taacttactc agcccagcat ccttcttctc ctcctggcag atcatttgta gcagatcaga 901 agagtataat agccatcagg ttttatgcga tggaacacct gagggaccac tattacgtaa 961 tcctggaaac catgacaaag ccaaaacccc caggctccca tcttcagcag atgtggaatt 1021 ttgtctgagt ttgacccagt atgaatctgg atcaatggat agaactgcca atttcagctt 1081 tagaaacaca ctggaaggat ttgccagtcc actcacaggg atagcagatc cttctcaaag 1141 tagcatgcac aatgccttac atatctttat gaatggaaca atgtcccaag tacagggatc 1201 ggccaacgat cccatttttc ttcttcacca tgcttttgtg gacagtattt ttgaacaatg 1261 gctgcgaagg caccgccctc ttttggaagt ttacccagaa gccaatgcac ctatcggcca 1321 taacagagac tcttacatgg ttcctttcat accgctctat agaaatggtg atttcttcat 1381 aacatccaag gatctgggat atgactacag ctacctccaa gagtcagatc caggctttta 1441 cagaaattat attgagcctt acttggaaca agccagtcgt atctggccat ggcttcttgg 1501 ggcagcactg gtgggagctg ttattgctgc agctctctct gggcttagca gtaggctatg 1561 ccttcagaag aagaagaaga agaagcaacc ccaggaggaa aggcagccac tcctcatgga 1621 caaagacgac taccacagct tgctgtatca gagccatctg tgaacatcct aggaaacaga 1681 gtgggactga aaggttttac ctcactcgac ctatttgttg gtgtttctac aaatttaaac 1741 tagtataaaa catagaccat agctgtttgg ctttttttca gacccatgtt ttttcctaag 1801 tcctagtttc taagaaatga ctgggatttg ctaaaatata tatatatata aataataact 1861 tactaatagc taaataaaat ttcctcttac aactaattga gctggttttt atgaatgtgt 1921 cttaattatt taaacttgag gcacattttt gttttcctta cttcattgtg aatttccaag 1981 aaaaatattc tctctctctc tctctctcgt gtgtttgtgt gtatgtgtgt gttaactgat 2041 tcaaacaatt ttgaaaatct tggattgata gaaatgattc attaatttat gaaattattt 2101 cattaatgat taggaaagac gaataattac taaattagta acagaggaga acatctgcca 2161 gcttttaatt aaattgtcat ttaagttacc ttatctacct tctgtgactg gtggaaaaat 2221 atcaggcaag agatgggaat gctctgccta ataggatagt ggctcctgga aggagtgggt 2281 tattactaga gattattacc tgaagtttac catagttaga aaattaatca aaacagatga 2341 ctcagtaaca tctgaagctt caagtcggct tgactgcaat ctgaaatcat caagcccaag 2401 agccaaagga atgggaacag cgatgggaaa ctatctgaat cagattctag tgtgatagtg 2461 tcaggggcac atgggtcatc tttgagacct tcacacctgt tgagtcacca aaatttgctg 2521 tgaatgtaaa tttttactgt aaattaattt tttcttttct ttttaaaaag atttatttat 2581 tattatacat aagtacactg tagctgtctt cagacacacc agaagagggt gtcagatctc 2641 attacagatg gttgtgagcc accatgtggt tgctgggatt tgaactcagg acctctggaa 2701 gaacagtcag tgctcttacc cgctgagcca tctcgccagt cccagtaaat ttttacttta 2761 gtgaaagtaa aatttaagtt ttagttttta gtttagtaaa attttaggaa gcaaattttt 2821 agttttctaa actaattttt ttttctagta ctggacatca acccagtgcc ttgtatatgc 2881 aatgcaagca ttttcttgta ctctgctacc tagcatgtat atataaatct acccaacaaa 2941 tgttcattac agctgacaag ggtctttata aactcagtgt ttccctttat cacaatacaa 3001 ttccctcctt tgccacttca tgtcatcata gaatattgtt tttttctcta gcggttcaag 3061 gtatgtattt gtatagcagt cacacctttg ataaaagtta ccatctcttt gattatatat 3121 ctcattatgg taacaaaatt atattatgac tatttcaata tatctgaaag tttcattaaa 3181 ttctcattaa ctttgtatat ttcagtcttg cttattgtga agcttttata aattgcttca 3241 ctttttttct gaaattgtcc tgttgctaca tcattctgtt aagaaataaa taagtggcaa 3301 tattttcc //