LOCUS Tyrp1 2623 bp mRNA linear ROD 19-SEP-2002 DEFINITION Mus musculus tyrosinase-related protein 1 (Tyrp1), mRNA. ACCESSION NM_031202 VERSION NM_031202.1 GI:13654240 KEYWORDS . SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. REFERENCE 1 (bases 1 to 2623) AUTHORS Shibahara,S., Tomita,Y., Sakakura,T., Nager,C., Chaudhuri,B. and Muller,R. TITLE Cloning and expression of cDNA encoding mouse tyrosinase JOURNAL Nucleic Acids Res. 14 (6), 2413-2427 (1986) MEDLINE 86176740 PUBMED 3008090 REFERENCE 2 (bases 1 to 2623) AUTHORS Jackson,I.J., Chambers,D.M., Budd,P.S. and Johnson,R. TITLE The tyrosinase-related protein-1 gene has a structure and promoter sequence very different from tyrosinase JOURNAL Nucleic Acids Res. 19 (14), 3799-3804 (1991) MEDLINE 91319534 PUBMED 1907365 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X03687.1. FEATURES Location/Qualifiers source 1..2623 /organism="Mus musculus" /db_xref="taxon:10090" /chromosome="4" /map="4 38.0 cM" gene 1..2623 /gene="Tyrp1" /note="synonyms: isa, TRP-1, brown" /db_xref="LocusID:22178" /db_xref="MGI:98881" CDS 175..1788 /gene="Tyrp1" /note="tyrosinase related protein; tyrosinase-related protein; iris stromal atrophy" /codon_start=1 /product="tyrosinase-related protein 1" /protein_id="NP_112479.1" /db_xref="GI:13654241" /db_xref="LocusID:22178" /db_xref="MGI:98881" /translation="MKSYNVLPLAYISLFLMLFYQVWAQFPRECANIEALRRGVCCPD LLPSSGPGTDPCGSSSGRGRCVAVIADSRPHSRHYPHDGKDDREAWPLRFFNRTCQCN DNFSGHNCGTCRPGWRGAACNQKILTVRRNLLDLSPEEKSHFVRALDMAKRTTHPQFV IATRRLEDILGPDGNTPQFENISVYNYFVWTHYYSVKKTFLGTGQESFGDVDFSHEGP AFLTWHRYHLLQLERDMQEMLQEPSFSLPYWNFATGKNVCDVCTDDLMGSRSNFDSTL ISPNSVFSQWRVVCESLEEYDTLGTLCNSTEGGPIRRNPAGNVGRPAVQRLPEPQDVT QCLEVRVFDTPPFYSNSTDSFRNTVEGYSAPTGKYDPAVRSLHNLAHLFLNGTGGQTH LSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNT EMFVTAPDNLGYAYEVQWPGQEFTVSEIITIAVVAALLLVAAIFGVASCLIRSRSTKN EANQPLLTDHYQRYAEDYEELPNPNHSMV" sig_peptide 175..246 /gene="Tyrp1" /note="putative" mat_peptide 247..1785 /gene="Tyrp1" /product="put. mature tyrosinase (aa 1-513)" misc_feature 535..1581 /gene="Tyrp1" /note="tyrosinase; Region: Common central domain of tyrosinase. This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372" /db_xref="CDD:pfam00264" misc_feature 460..468 /gene="Tyrp1" /note="pot. glycosylation site" misc_feature 484..492 /gene="Tyrp1" /note="pot. glycosylation site" misc_feature 715..723 /gene="Tyrp1" /note="pot. glycosylation site" misc_feature 1084..1092 /gene="Tyrp1" /note="pot. glycosylation site" misc_feature 1221..1229 /gene="Tyrp1" /note="pot. glycosylation site" misc_feature 1327..1335 /gene="Tyrp1" /note="pot. glycosylation site" misc_feature 1721..1729 /gene="Tyrp1" /note="pot. glycosylation site" misc_feature 1906..1911 /gene="Tyrp1" /note="put. polyA signal" polyA_site 1928 /gene="Tyrp1" /note="alternate polyA site" variation 1934 /gene="Tyrp1" /allele="A" /allele="G" /db_xref="dbSNP:3091051" variation 1948 /gene="Tyrp1" /allele="C" /allele="T" /db_xref="dbSNP:3022980" variation 1989 /gene="Tyrp1" /allele="A" /allele="G" /db_xref="dbSNP:3091053" variation 1999 /gene="Tyrp1" /allele="C" /allele="T" /db_xref="dbSNP:3091054" variation 2020 /gene="Tyrp1" /allele="G" /allele="T" /db_xref="dbSNP:3022981" misc_feature 2592..2597 /gene="Tyrp1" /note="pot. polyA signal" misc_feature 2601..2606 /gene="Tyrp1" /note="pot. polyA signal" polyA_site 2623 /gene="Tyrp1" /note="polyA site" BASE COUNT 701 a 614 c 571 g 737 t ORIGIN 1 caattaacag ctggcatcag gggaaaagca gacatccaac aacactagct ctgaaggaga 61 tcagcagaga aaccttccag ggattcatgc tgtattttca tctgagcacc cctgtcttct 121 ccatgcaaag agcagcatag gagacctgtg ttctgaactc ttgcttcgag aagaatgaaa 181 tcttacaacg tcctccccct agcctatatc tcccttttcc tgatgctgtt ttatcaggtt 241 tgggctcagt ttccacgaga gtgtgccaat attgaggctc tgagacgtgg ggtgtgttgc 301 ccagacctgc tcccttcctc tggaccgggg actgaccctt gtggctcatc atcaggaaga 361 ggcaggtgtg tggctgtgat tgcagactcc cgaccccaca gccgccatta tccccacgat 421 ggtaaagatg accgagaagc ctggcctctg aggttcttta atagaacatg tcagtgcaat 481 gataatttct caggacacaa ctgtgggact tgccgtcctg ggtggagagg agctgcatgc 541 aaccagaaaa ttctcacagt caggagaaat cttctagact taagtccaga agaaaagagc 601 cactttgtca gggccttgga tatggcgaag cgcacaactc accctcaatt tgtcattgcc 661 acaaggaggt tagaagacat actgggacca gatggcaaca caccacaatt tgagaacatt 721 tccgtttata actactttgt ttggacacac tattattcag tcaaaaaaac cttcctcggg 781 acaggacagg aaagctttgg ggatgtggat ttctctcacg aaggacccgc ttttctcaca 841 tggcacaggt accatctgct gcagctggag agagacatgc aggagatgct gcaggagcct 901 tctttctccc ttccttactg gaattttgca actgggaaaa acgtctgcga tgtctgcact 961 gatgacttga tgggatccag aagcaacttc gattctactc ttataagccc caactctgtc 1021 ttttctcaat ggagagtggt ctgtgaatcc ttggaagagt acgataccct gggaacactt 1081 tgtaacagca ctgagggtgg accaatcagg agaaacccag ctggaaatgt agggagacca 1141 gcagtgcagc gtcttcctga gccacaggat gtcactcagt gcttggaggt ccgtgtattt 1201 gacacacctc ctttttattc caattctaca gacagttttc gaaatacagt ggaaggttac 1261 agtgctccca cgggaaaata tgaccctgct gttcgaagcc ttcacaacct ggcccacctc 1321 ttcctgaatg gaacgggagg acaaacccat ttgtctccca atgatcctat ttttgtcctc 1381 ctgcacactt tcactgatgc ggtctttgac gaatggctaa ggaggtataa cgccgatatt 1441 tctaccttcc cgttggaaaa cgcacctatt ggacataaca ggcaatacaa catggtgcca 1501 ttctggcctc cagttaccaa cacagaaatg tttgttactg ctccagacaa tctgggatat 1561 gcttatgaag ttcaatggcc aggtcaggag tttactgtat ctgaaatcat taccattgct 1621 gtagtggctg cgttgttact tgtagctgcc attttcgggg ttgcttcttg tctgatccgt 1681 tctagaagca ccaagaatga agccaaccag cctctcctca ctgatcacta tcaacgctat 1741 gctgaggact atgaggagct cccgaatcct aaccactcca tggtctgata gccgcctgcc 1801 catccccgca cgcagcaggt tgggaagcaa cctgattgaa acacagctgt caaccgtatt 1861 tcctttggct tccttctttt cttcccaaga tagatgtggt ttggaattaa agcattgctc 1921 tccagtgatg acagtttaga ctccttttaa tgggttttaa taattagttc tattgaagat 1981 ggcaaattat accagttgtg tgatatctga gaggataatt ggatgaactt ggtggtattc 2041 taaagatggc ctgtatgctg tgaaaaagca atgctttgtt tacacaggaa aaataagttt 2101 gatgtaaaat ctctatttca aatatatgag tgcccattct tatggagtta acatgtgaat 2161 gcattgttat tgttggtact aatcaaaagt tataaaagca gccatgttga ttagttacaa 2221 caaatcacat gacattataa acaaatagaa tcctgattat ctttctgaaa ctgctctcat 2281 tttgctttca gcgtattatt tggcctcagg tgcaaggcca ccacaaagtc acagtccttg 2341 ccacacatgg taaagacgaa agcttcactt gctggaacac atctgctctt gcatatttgc 2401 caatgtgttc cctagctcag ttctctggac atgaaactgc ctgggccaca gttcacctct 2461 aattctcgta tcttagaggc ctgcgaggaa ggtatcagtc agaggacaca atgttctgtg 2521 catcttatca aatgttgtat ttcatttcaa cagcattgtt acaccactta tcagccttct 2581 gtgtatttca aaataaatat aataaaatct tctttcattg gtt //